Low-dose CT for the spatial normalization of PET images: A validation procedure for amyloid-PET semi-quantification.

ABSTRACT: The reference standard for spatial normalization of brain positron emission tomography (PET) images involves structural Magnetic Resonance Imaging (MRI) data. However, the lack of such structural information is fairly common in clinical settings. This might lead to lack of proper image quantification and to evaluation based only on visual ratings, which does not allow research studies or clinical trials based on quantification. PET/CT systems are widely available and CT normalization procedures need to be explored. Here we describe and validate a procedure for the spatial normalization of PET images based on the low-dose Computed Tomography (CT) images contextually acquired for attenuation correction in PET/CT systems. We included N = 34 subjects, spanning from cognitively normal to

SUBMITTER: Presotto L 

PROVIDER: S-EPMC6072675 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature