Symptom-related sputum microbiota in stable chronic obstructive pulmonary disease.

ABSTRACT:

Background

The role of airway microbiota in COPD is highly debated. Symptomology assessment is vital for the management of clinically stable COPD patients; however, the link between symp toms and the airway microbiome is currently unknown.

Purpose

The present study aimed to evaluate the relationship among stable COPD patients.

Patients and methods

We conducted pyrosequencing of bacterial 16S rRNA using induced sputum samples in a Han Chinese cohort that included 40 clinically stable COPD patients and 19 healthy controls.

Results

Alterations in community composition and core bacte rial taxa (Neisseria subflava, etc.) were observed in patients with severe symptoms compared with controls. The co-occurrence network indicated that the key microbiota enriched in COPD

SUBMITTER: Diao W 

PROVIDER: S-EPMC6072682 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature