Discovery of nonnucleoside inhibitors of polymerase from infectious pancreatic necrosis virus (IPNV).

ABSTRACT:

Introduction

Infectious pancreatic necrosis virus (IPNV) causes serious losses in several fish species of commercial interest. IPNV is a non-enveloped double-stranded RNA virus with a genome consisting of two segments A and B. Segment B codes for the VP1 protein, a non-canonical RNA-dependent RNA polymerase that can be found both in its free form and linked to the end of genomic RNA, an essential enzyme for IPNV replication.

Materials and methods

We take advantage of the knowledge over the allosteric binding site described on the surface of the thumb domain of Hepatitis C virus (HCV) polymerase to design new non-nucleoside inhibitors against the IPNV VP1 polymerase.

Results

Molecular docking techniques have been used to screen a chemical library of 23,760 compounds ov

SUBMITTER: Bello-Perez M 

PROVIDER: S-EPMC6072831 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature