A Glutamatergic Spine Model to Enable Multi-Scale Modeling of Nonlinear Calcium Dynamics.

ABSTRACT: In synapses, calcium is required for modulating synaptic transmission, plasticity, synaptogenesis, and synaptic pruning. The regulation of calcium dynamics within neurons involves cellular mechanisms such as synaptically activated channels and pumps, calcium buffers, and calcium sequestrating organelles. Many experimental studies tend to focus on only one or a small number of these mechanisms, as technical limitations make it difficult to observe all features at once. Computational modeling enables incorporation of many of these properties together, allowing for more complete and integrated studies. However, the scale of existing detailed models is often limited to synaptic and dendritic compartments as the computational burden rapidly increases when these models are integrated in cellular

SUBMITTER: Hu E 

PROVIDER: S-EPMC6072875 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature