Ontology highlight
ABSTRACT:
SUBMITTER: Roitenberg N
PROVIDER: S-EPMC6073070 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
EMBO reports 20180626 8
Reducing insulin/IGF-1 signaling (IIS) extends lifespan, promotes protein homeostasis (proteostasis), and elevates stress resistance of worms, flies, and mammals. How these functions are orchestrated across the organism is only partially understood. Here, we report that in the nematode <i>Caenorhabditis elegans,</i> the IIS positively regulates the expression of <i>caveolin-1</i> (<i>cav-1</i>), a gene which is primarily expressed in neurons of the adult worm and underlies the formation of caveo ...[more]