Polyphenols Derived from Lychee Seed Suppress Aβ (1-42)-Induced Neuroinflammation.

ABSTRACT: Amyloid-β (Aβ) is commonly recognized as the most important factor that results in neuronal cell death and accelerates the progression of Alzheimer's disease (AD). Increasing evidence suggests that microglia activated by Aβ release an amount of neurotoxic inflammatory cytokines that contribute to neuron death and aggravate AD pathology. In our previous studies, we found that lychee seed fraction (LSF), an active fraction derived from the lychee seed, could significantly improve the cognitive function of AD rats and inhibit Aβ-induced neuroinflammation in vitro, and decrease neuronal injuries in vivo and in vitro. In the current study, we aimed to isolate and identify the specific components in LSF that were responsible for the anti-neuroinflammation effect using preparative high performanc

SUBMITTER: Tang Y 

PROVIDER: S-EPMC6073121 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature