Neuroprotective Effects of Soy Isoflavones on Scopolamine-Induced Amnesia in Mice.

ABSTRACT: In the recent years, interest in soybean as a neuroprotective nutrient in the management of Alzheimer’s disease (AD) has increased and soy isoflavones (SI), as kinds of soybean phytochemicals, are thought to be biologically active components that confer this beneficial effect against neurodegenerative diseases. However, the neuroprotective effect of SI is not well understood. Therefore, the present study (30 days) was conducted to investigate the neuroprotective effects of soy isoflavones (SI) on scopolamine (SCOP)-induced memory impairments in Institute of Cancer Research (ICR) mice (aged 4 weeks) and to elucidate its underlying mechanisms of action. SI (40 mg/kg) administration improved the cognitive performance of SCOP-treated mice in an object location recognition task and the Mo

SUBMITTER: Lu C 

PROVIDER: S-EPMC6073222 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature