Presence of HCV RNA in peripheral blood mononuclear cells may predict patients response to interferon and ribavirin therapy.

ABSTRACT:

Background and objectives

Hepatitis C virus (HCV) is considered a hepatotropic virus, but it can repli.cate in peripheral blood mononuclear cells (PBMCs), which influence the sustained virological response (SVR) of the patients, as well as relapse in successfully treated patients. The main objective of this study was to establish the importance of PBMC HCV RNA detection as a primary test to declare the patient as a responder, and the secondary objective was to investigate the risk of non-SVR or relapse in individuals who showed an end-of-treatment (ETR).

Design and settings

Blood samples were collected after the completion of 6 months of therapy, and they were collected 6 months after the completion of treatment.

Patients and methods

A total 103 patients infected with

SUBMITTER: Zaman N 

PROVIDER: S-EPMC6074557 | biostudies-literature | 2014 Sep-Oct

REPOSITORIES: biostudies-literature