Insertion/deletion polymorphism of the ACE gene increased risk of Behcet disease: evidence from a meta-analysis.

ABSTRACT:

Background and objectives

Endothelial dysfunction has a role in the development of the Behcet disease (BD). Local renin-angiotensin system (RAS) plays a crucial role in the endothelial control, and angiotensin-converting enzyme (ACE) is the monitoring component of the RAS. We investigated the relationship between the ACE Ins/Del (I/D) variants and the risk of BD.

Design and settings

A meta-analysis was conducted from all published studies on the associations be.tween the ACE I/D polymorphism and BD.

Methods

We systemically searched all published studies from PubMed and EMBASE, and data were quantitatively synthesized. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated for allele, homozygous, heterozygous, and combined genetic models.

Re

SUBMITTER: Mandal RK 

PROVIDER: S-EPMC6074878 | biostudies-literature | 2013 Sep-Oct

REPOSITORIES: biostudies-literature