The genomic landscape of African populations in health and disease.

ABSTRACT: A deeper appreciation of the complex architecture of African genomes is critical to the global effort to understand human history, biology and differential distribution of disease by geography and ancestry. Here, we report on how the growing engagement of African populations in genome science is providing new insights into the forces that shaped human genomes before and after the Out-of-Africa migrations. As a result of this human evolutionary history, African ancestry populations have the greatest genomic diversity in the world, and this diversity has important ramifications for genomic research. In the case of pharmacogenomics, for instance, variants of consequence are not limited to those identified in other populations, and diversity within African ancestry populations precludes summar

SUBMITTER: Rotimi CN 

PROVIDER: S-EPMC6075021 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature