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Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.

ABSTRACT: Large-scale meta-analyses of genome-wide association studies (GWAS) have identified?>175 loci associated with fasting cholesterol levels, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG). With differences in linkage disequilibrium (LD) structure and allele frequencies between ancestry groups, studies in additional large samples may detect new associations. We conducted staged GWAS meta-analyses in up to 69,414 East Asian individuals from 24 studies with participants from Japan, the Philippines, Korea, China, Singapore, and Taiwan. These meta-analyses identified (P?

SUBMITTER: Spracklen CN 

PROVIDER: S-EPMC6075203 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.

Spracklen Cassandra N CN   Chen Peng P   Kim Young Jin YJ   Wang Xu X   Cai Hui H   Li Shengxu S   Long Jirong J   Wu Ying Y   Wang Ya Xing YX   Takeuchi Fumihiko F   Wu Jer-Yuarn JY   Jung Keum-Ji KJ   Hu Cheng C   Akiyama Koichi K   Zhang Yonghong Y   Moon Sanghoon S   Johnson Todd A TA   Li Huaixing H   Dorajoo Rajkumar R   He Meian M   Cannon Maren E ME   Roman Tamara S TS   Salfati Elias E   Lin Keng-Hung KH   Guo Xiuqing X   Sheu Wayne H H WHH   Absher Devin D   Adair Linda S LS   Assimes Themistocles L TL   Aung Tin T   Cai Qiuyin Q   Chang Li-Ching LC   Chen Chien-Hsiun CH   Chien Li-Hsin LH   Chuang Lee-Ming LM   Chuang Shu-Chun SC   Du Shufa S   Fan Qiao Q   Fann Cathy S J CSJ   Feranil Alan B AB   Friedlander Yechiel Y   Gordon-Larsen Penny P   Gu Dongfeng D   Gui Lixuan L   Guo Zhirong Z   Heng Chew-Kiat CK   Hixson James J   Hou Xuhong X   Hsiung Chao Agnes CA   Hu Yao Y   Hwang Mi Yeong MY   Hwu Chii-Min CM   Isono Masato M   Juang Jyh-Ming Jimmy JJ   Khor Chiea-Chuen CC   Kim Yun Kyoung YK   Koh Woon-Puay WP   Kubo Michiaki M   Lee I-Te IT   Lee Sun-Ju SJ   Lee Wen-Jane WJ   Liang Kae-Woei KW   Lim Blanche B   Lim Sing-Hui SH   Liu Jianjun J   Nabika Toru T   Pan Wen-Harn WH   Peng Hao H   Quertermous Thomas T   Sabanayagam Charumathi C   Sandow Kevin K   Shi Jinxiu J   Sun Liang L   Tan Pok Chien PC   Tan Shu-Pei SP   Taylor Kent D KD   Teo Yik-Ying YY   Toh Sue-Anne SA   Tsunoda Tatsuhiko T   van Dam Rob M RM   Wang Aili A   Wang Feijie F   Wang Jie J   Wei Wen Bin WB   Xiang Yong-Bing YB   Yao Jie J   Yuan Jian-Min JM   Zhang Rong R   Zhao Wanting W   Chen Yii-Der Ida YI   Rich Stephen S SS   Rotter Jerome I JI   Wang Tzung-Dau TD   Wu Tangchun T   Lin Xu X   Han Bok-Ghee BG   Tanaka Toshihiro T   Cho Yoon Shin YS   Katsuya Tomohiro T   Jia Weiping W   Jee Sun-Ha SH   Chen Yuan-Tsong YT   Kato Norihiro N   Jonas Jost B JB   Cheng Ching-Yu CY   Shu Xiao-Ou XO   He Jiang J   Zheng Wei W   Wong Tien-Yin TY   Huang Wei W   Kim Bong-Jo BJ   Tai E-Shyong ES   Mohlke Karen L KL   Sim Xueling X  

Human molecular genetics 20170501 9

Large-scale meta-analyses of genome-wide association studies (GWAS) have identified >175 loci associated with fasting cholesterol levels, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG). With differences in linkage disequilibrium (LD) structure and allele frequencies between ancestry groups, studies in additional large samples may detect new associations. We conducted staged GWAS meta-analyses in  ...[more]

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