Human methionine synthase A2756G polymorphism increases susceptibility to prostate cancer.

ABSTRACT:

Background/aims

Previous results on the association between MTR gene A2756G polymorphism and PCa risk are inconclusive.

Methods

We used odds ratios (ORs) with corresponding 95% confidence intervals (95% CIs) to evaluate the correlation between MTR A2756G polymorphism and risk of PCa in meta-analysis. Serum expression of MTR was detected by ELISA and in-silico tools were utilized to assess this variant.

Results

Our study included 2,921 PCa patients and 3,095 control subjects. The results indicated that the MTR A2756G polymorphism is linked with an increased risk of PCa using three genetic models (G-allele vs. A-allele: OR = 1.16, 95%CI = 1.04 - 1.30; GA vs. AA: OR = 1.17, 95%CI = 1.02 - 1.33; GG+GA vs. AA: OR = 1.18, 95%CI = 1.04 - 1.34). Stratified analysis pro

SUBMITTER: Shao HB 

PROVIDER: S-EPMC6075445 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature