Preconception maternal lipoprotein levels in relation to fecundability.

ABSTRACT:

Study question

Are maternal preconception lipid levels associated with fecundability?

Summary answer

Fecundability was reduced for all abnormal female lipid levels including total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and total triglyceride levels.

What is known already

Subfecundity affects 7-15% of the population and lipid disorders are hypothesized to play a role since cholesterol acts as a substrate for the synthesis of steroid hormones. Evidence illustrating this relationship at the mechanistic level is mounting but few studies in humans have explored the role of preconception lipids in fecundity.

Study design, size, duration

A secondary analysis of the Effects of Aspirin in Gestation and Repr

SUBMITTER: Pugh SJ 

PROVIDER: S-EPMC6075456 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature