Evaluation of a Live Attenuated Human Metapneumovirus Vaccine in Adults and Children.

ABSTRACT: We conducted a phase I clinical trial of an experimental live attenuated recombinant human metapneumovirus (HMPV) vaccine (rHMPV-Pa) sequentially in adults, HMPV-seropositive children, and HMPV-seronegative children, the target population for vaccination. rHMPV-Pa was appropriately restricted in replication in adults and HMPV-seropositive children but was overattenuated for HMPV-seronegative children.

SUBMITTER: Karron RA 

PROVIDER: S-EPMC6075531 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature