Long-term Effects on Cognitive Trajectories of Postmenopausal Hormone Therapy in Two Age Groups.

ABSTRACT:

Background

Postmenopausal hormone therapy may have long-term effects on cognitive function depending on women's age.

Methods

Postintervention follow-up was conducted with annual cognitive assessments of two randomized controlled clinical trial cohorts, beginning an average of 6-7 years after study medications were terminated: 1,376 women who had enrolled in the Women's Health Initiative when aged 50-54 years and 2,880 who had enrolled when aged 65-79 years. Women had been randomly assigned to 0.625mg/d conjugated equine estrogens (CEE) for those with prior hysterectomy (mean 7.1 years), CEE with 2.5mg/d medroxyprogesterone acetate for those without prior hysterectomy (mean 5.4 years), or matching placebos.

Results

Hormone therapy, when prescribed to women aged 50-54 y

SUBMITTER: Espeland MA 

PROVIDER: S-EPMC6075542 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature