Mild traumatic brain injury is associated with reduced cortical thickness in those at risk for Alzheimer's disease.

ABSTRACT: Moderate-to-severe traumatic brain injury is one of the strongest environmental risk factors for the development of neurodegenerative diseases such as late-onset Alzheimer's disease, although it is unclear whether mild traumatic brain injury, or concussion, also confers risk. This study examined mild traumatic brain injury and genetic risk as predictors of reduced cortical thickness in brain regions previously associated with early Alzheimer's disease, and their relationship with episodic memory. Participants were 160 Iraq and Afghanistan War veterans between the ages of 19 and 58, many of whom carried mild traumatic brain injury and post-traumatic stress disorder diagnoses. Whole-genome polygenic risk scores for the development of Alzheimer's disease were calculated using summary statisti

SUBMITTER: Hayes JP 

PROVIDER: S-EPMC6075586 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature