Inhibitors of the HIV-1 capsid, a target of opportunity.

ABSTRACT:

Purpose of review

To summarize recent advances in the discovery of chemical inhibitors targeting the HIV capsid and research on their mechanisms of action.

Recent findings

HIV infection is critically dependent on functions of the viral capsid. Numerous studies have reported the identification of a variety of compounds that bind to the capsid protein; some of these inhibit reverse transcription and nuclear entry, steps required for infection. Other capsid-targeting compounds appear to act by perturbing capsid assembly, resulting in noninfectious progeny virions. Inhibitors may bind to several different positions on the capsid protein, including sites in both protein domains. However, the antiviral activity of many reported capsid-targeting inhibitors has not been definitively

SUBMITTER: Carnes SK 

PROVIDER: S-EPMC6075716 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature