Ontology highlight
ABSTRACT:
SUBMITTER: Shen H
PROVIDER: S-EPMC6075738 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Cell reports 20180601 11
We studied 137 primary testicular germ cell tumors (TGCTs) using high-dimensional assays of genomic, epigenomic, transcriptomic, and proteomic features. These tumors exhibited high aneuploidy and a paucity of somatic mutations. Somatic mutation of only three genes achieved significance-KIT, KRAS, and NRAS-exclusively in samples with seminoma components. Integrated analyses identified distinct molecular patterns that characterized the major recognized histologic subtypes of TGCT: seminoma, embryo ...[more]