Mother-to-child transmission of Chikungunya virus: A systematic review and meta-analysis.

ABSTRACT:

Background

Chikungunya virus (CHIKV) is an emerging arboviral infection with a global distribution and may cause fetal and neonatal infections after maternal CHIKV-infections during gestation.

Methodology

We performed a systematic review to evaluate the risk for: a) mother-to-child transmission (MTCT), b) antepartum fetal deaths (APFD), c) symptomatic neonatal disease, and d) neonatal deaths from maternal CHIKV-infections during gestation. We also recorded the neonatal clinical manifestations after such maternal infections (qualitative data synthesis). We searched PubMed (last search 3/2017) for articles, of any study design, with any of the above outcomes. We calculated the overall risk of MTCT, APFDs and risk of symptomatic neonatal disease by simple pooling. For endpoints

SUBMITTER: Contopoulos-Ioannidis D 

PROVIDER: S-EPMC6075784 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature