FusionPathway: Prediction of pathways and therapeutic targets associated with gene fusions in cancer.

ABSTRACT: Numerous gene fusions have been uncovered across multiple cancer types. Although the ability to target several of these fusions has led to the development of some successful anti-cancer drugs, most of them are not druggable. Understanding the molecular pathways of a fusion is important in determining its function in oncogenesis and in developing therapeutic strategies for patients harboring the fusion. However, the molecular pathways have been elucidated for only a few fusions, in part because of the labor-intensive nature of the required functional assays. Therefore, we developed a domain-based network approach to infer the pathways of a fusion. Molecular interactions of a fusion are first predicted by using its protein domain composition, and its associated pathways are then inferred fro

SUBMITTER: Wu CC 

PROVIDER: S-EPMC6075785 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature