Elevated heat shock proteins in bipolar disorder patients with hypothalamic pituitary adrenal axis dysfunction.

ABSTRACT:

Background

Heat shock proteins (HSP) might be useful as biomarkers for bipolar disorder (BD) which would be clinically valuable since no reliable biomarker for BD has so far been identified. The purpose of this study was to assess the heat shock proteins CPN10, CPN60, and CPN70 as potential biomarkers of BD.

Methods

The study included 100 BD patients recruited from a hospital during 2012 and 2013. The study also included 94 healthy controls. Among the BD patients, 33 had abnormal hypothalamic-pituitary-adrenal (HPA) axis activity. Blood samples were obtained from the patients and controls. The chemiluminescence method, mass spectrometry, and flow cytometry were used for analysis.

Results

The BD patients compared with the controls had a significantly lower level of CPN

SUBMITTER: Cheng Y 

PROVIDER: S-EPMC6076087 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature