Low expression of aging-related NRXN3 is associated with Alzheimer disease: A systematic review and meta-analysis.

ABSTRACT:

Background

Alzheimer disease (AD) is a common neurodegenerative disorder with distinct pathological features, with aging considered the greatest risk factor. We explored how aging contributes to increased AD risk, and determined concurrent and coordinate changes (including genetic and phenotypic modifications) commonly exhibited in both normal aging and AD.

Methods

Using the Gene Expression Omnibus (GEO) database, we collected 1 healthy aging-related and 3 AD-related datasets of the hippocampal region. The normal aging dataset was divided into 3 age groups: young (20-40 years old), middle-aged (40-60 years old), and elderly (>60 years old). These datasets were used to analyze the differentially expressed genes (DEGs). The Gene Ontology (GO) terms, pathways, and function netw

SUBMITTER: Zheng JJ 

PROVIDER: S-EPMC6076205 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature