Phenotype-oriented network analysis for discovering pharmacological effects of natural compounds.

ABSTRACT: Although natural compounds have provided a wealth of leads and clues in drug development, the process of identifying their pharmacological effects is still a challenging task. Over the last decade, many in vitro screening methods have been developed to identify the pharmacological effects of natural compounds, but they are still costly processes with low productivity. Therefore, in silico methods, primarily based on molecular information, have been proposed. However, large-scale analysis is rarely considered, since many natural compounds do not have molecular structure and target protein information. Empirical knowledge of medicinal plants can be used as a key resource to solve the problem, but this information is not fully exploited and is used only as a preliminary tool for selecting pla

SUBMITTER: Yoo S 

PROVIDER: S-EPMC6076245 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature