A study of generalizability of recurrent neural network-based predictive models for heart failure onset risk using a large and heterogeneous EHR data set.

ABSTRACT: Recently, recurrent neural networks (RNNs) have been applied in predicting disease onset risks with Electronic Health Record (EHR) data. While these models demonstrated promising results on relatively small data sets, the generalizability and transferability of those models and its applicability to different patient populations across hospitals have not been evaluated. In this study, we evaluated an RNN model, RETAIN, over Cerner Health Facts® EMR data, for heart failure onset risk prediction. Our data set included over 150,000 heart failure patients and over 1,000,000 controls from nearly 400 hospitals. Convincingly, RETAIN achieved an AUC of 82% in comparison to an AUC of 79% for logistic regression, demonstrating the power of more expressive deep learning models for EHR predictive model

SUBMITTER: Rasmy L 

PROVIDER: S-EPMC6076336 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature