The Association of Obesity and Cardiometabolic Traits With Incident HFpEF and HFrEF.

ABSTRACT:

Objectives

This study evaluated the associations of obesity and cardiometabolic traits with incident heart failure with preserved versus reduced ejection fraction (HFpEF vs. HFrEF). Given known sex differences in HF subtype, we examined men and women separately.

Background

Recent studies suggest that obesity confers greater risk of HFpEF versus HFrEF. Contributions of associated metabolic traits to HFpEF are less clear.

Methods

We studied 22,681 participants from 4 community-based cohorts followed for incident HFpEF versus HFrEF (ejection fraction ≥50% vs. <50%). We evaluated the association of body mass index (BMI) and cardiometabolic traits with incident HF subtype using Cox models.

Results

The mean age was 60 ± 13 years, and 53% were women. Over a median fol

SUBMITTER: Savji N 

PROVIDER: S-EPMC6076337 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature