The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.

ABSTRACT: Oligodendrogliomas are brain tumors accounting for approximately 10% of all central nervous system cancers. CIC is a transcription factor that is mutated in most patients with oligodendrogliomas; these mutations are believed to be a key oncogenic event in such cancers. Analysis of the Drosophila melanogaster ortholog of CIC, Capicua, indicates that CIC loss phenocopies activation of the EGFR/RAS/MAPK pathway, and studies in mammalian cells have demonstrated a role for CIC in repressing the transcription of the PEA3 subfamily of ETS transcription factors. Here, we address the mechanism by which CIC represses transcription and assess the functional consequences of CIC inactivation. Genome-wide binding patterns of CIC in several cell types revealed that CIC target genes were enriched f

SUBMITTER: Weissmann S 

PROVIDER: S-EPMC6076439 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature