Surface modification of polymer nanoparticles with native albumin for enhancing drug delivery to solid tumors.

ABSTRACT: Albumin is a promising surface modifier of nanoparticulate drug delivery systems. Serving as a dysopsonin, albumin can protect circulating nanoparticles (NPs) from the recognition and clearance by the mononuclear phagocytic system (MPS). Albumin may also help transport the NPs to solid tumors based on the increased consumption by cancer cells and interactions with the tumor microenvironment. Several studies have explored the benefits of surface-bound albumin to enhance NP delivery to tumors. However, it remains unknown how the surface modification process affects the conformation of albumin and the performance of the albumin-modified NPs. We use three different surface modification methods including two prevalent approaches (physisorption and interfacial embedding) and a new method based o

SUBMITTER: Hyun H 

PROVIDER: S-EPMC6076859 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature