Obesity's effect on asthma extends to diagnostic criteria.

ABSTRACT:

Background

The use of inflammatory biomarkers to delineate the type of lung inflammation present in asthmatic subjects is increasingly common. However, the effect of obesity on these markers is unknown.

Objectives

We aimed to determine the effect of obesity on conventional markers of inflammation in asthmatic subjects.

Methods

We performed secondary analysis of data from 652 subjects previously enrolled in 2 Asthma Clinical Research Network trials. We performed linear correlations between biomarkers and logistic regression analysis to determine the predictive value of IgE levels, blood eosinophil counts, and fraction of exhaled nitric oxide values in relationship to sputum eosinophil counts (>2%), as well as to determine whether cut points existed that would maximize

SUBMITTER: Lugogo N 

PROVIDER: S-EPMC6076889 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature