Single nucleotide polymorphisms within HLA region are associated with disease relapse for patients with unrelated cord blood transplantation.

ABSTRACT: Disease relapse occurs in unrelated cord blood transplantation (CBT) even when the alleles of human leukocyte antigen (HLA) are fully matched between donor and recipient. This is similar to that observed in other types of hematopoietic stem cell transplantation. Fourteen single nucleotide polymorphisms (SNPs) within the HLA region have been reported previously by Petersdorf et al. and Piras et al. as transplantation determinants in unrelated hematopoietic cell transplantation. In this study, the genomic sequences within 500 base pairs upstream and downstream of the fourteen transplantation-related SNPs from 53 patients and their HLA-matched unrelated donors were analyzed for determining whether or not genetic variants, conferred by either recipient or donor SNP genotype or by recipient-don

SUBMITTER: Chen DP 

PROVIDER: S-EPMC6076982 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature