Responsiveness of Single versus Composite Measures of Pain in Knee Osteoarthritis.

ABSTRACT:

Objective

In rheumatoid arthritis, composite outcomes constructed from a combination of outcome measures are widely used to enhance responsiveness (sensitivity to change) and comprehensively summarize response. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain is the primary outcome measure in many osteoarthritis (OA) trials. Information from other outcomes, such as rescue medication use and other WOMAC subscales, could be added to create composite outcomes, but the sensitivity of such a composite has not been tested.

Methods

We used data from a completed trial of tanezumab for knee OA (NCT00733902). The WOMAC questionnaire and rescue medication use were measured at several timepoints, up to 16 weeks. Pain and rescue medication outcomes were standar

SUBMITTER: Parkes MJ 

PROVIDER: S-EPMC6076998 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature