Levels of Resistance to Pyrethroid among Distinct kdr Alleles in Aedes aegypti Laboratory Lines and Frequency of kdr Alleles in 27 Natural Populations from Rio de Janeiro, Brazil.

ABSTRACT:

Background

Several mutations in voltage gated sodium channel (Na_V) have been identified in Aedes aegypti populations worldwide. However, only few are related to knockdown resistance to pyrethroids, most of which with variations in the 1016 and 1534 Na_V sites. In Brazil, at least two Na_V alleles are known: Na_VR1, with a substitution in the 1534 (1016 Val⁺ + 1534 Ile ^kdr ) and Na_VR2, with substitutions in both 1016 and sites (1016Ile^kdr + 1534Cys ^kdr ). There is also the duplication in the Na_V gene, with one copy carrying the substitution Ile1011Met, although its effects on pyrethroid resistance remain to be clarified. Our goal

SUBMITTER: Brito LP 

PROVIDER: S-EPMC6077680 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature