Combination of Genetic Markers and Age Effectively Facilitates the Identification of People with High Risk of Preeclampsia in the Han Chinese Population.

ABSTRACT:

Objective

This study aimed to analyze the possible association between known genetic risks and preeclampsia in a Han Chinese population.

Methods

A total of 156 patients with preeclampsia and 286 healthy Han Chinese women were enrolled and genotyped for 27 genetic alleles associated with preeclampsia in different populations. The association between the genotypes of the individual alleles and preeclampsia and the possible interaction among the alleles were analyzed. Finally logistic models were trained with the genotypes of possible alleles contributing to preeclampsia.

Results

Seven alleles were significantly or marginally significantly associated with preeclampsia, which involved six genes (rs4762 in AGT, rs1800896 in IL-10, rs1800629 and rs1799724 in <

SUBMITTER: Zhou L 

PROVIDER: S-EPMC6077688 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature