Time-resolved neural reinstatement and pattern separation during memory decisions in human hippocampus.

ABSTRACT: Mnemonic decision-making has long been hypothesized to rely on hippocampal dynamics that bias memory processing toward the formation of new memories or the retrieval of old ones. Successful memory encoding may be best optimized by pattern separation, whereby two highly similar experiences can be represented by underlying neural populations in an orthogonal manner. By contrast, successful memory retrieval is thought to be supported by a recovery of the same neural pattern laid down during encoding. Here we examined how hippocampal pattern completion and separation emerge over time during memory decisions. We measured electrocorticography activity in the human hippocampus and posterior occipitotemporal cortex (OTC) while participants performed continuous recognition of items that were new, r

SUBMITTER: Lohnas LJ 

PROVIDER: S-EPMC6077719 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature