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T₁- and T₂-weighted Magnetic Resonance Dual Contrast by Single Core Truncated Cubic Iron Oxide Nanoparticles with Abrupt Cellular Internalization and Immune Evasion.

ABSTRACT: Conventional T₁- or T₂-weighted single mode contrast-enhanced magnetic resonance imaging (MRI) may produce false results. Thereby, there is a need to develop dual contrast agents, T₁- and T₂-weighted, for more accurate MRI imaging. The dual contrast agents should possess high magnetic resonance (MR) relaxivities, targeted tumor linking, and minimum recognition by the immune system. We have developed nitrodopamine-PEG grafted single core truncated cubic iron oxide nanoparticles (ND-PEG-tNCIOs) capable of producing marked dual contrasts in MRI with enhanced longitudinal and transverse relaxivities of 32 ± 1.29 and 791 ± 38.39 mM^-1 s^-1, respectively. Furthermore, the ND-PEG-tNCIOs show excellent colloidal stability in physiolog

SUBMITTER: Thapa B

PROVIDER: S-EPMC6077774 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Dataset Information

T₁- and T₂-weighted Magnetic Resonance Dual Contrast by Single Core Truncated Cubic Iron Oxide Nanoparticles with Abrupt Cellular Internalization and Immune Evasion.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

T1- and T2-weighted Magnetic Resonance Dual Contrast by Single Core Truncated Cubic Iron Oxide Nanoparticles with Abrupt Cellular Internalization and Immune Evasion.

OmicsDI is part of the ELIXIR infrastructure

Tweets

T₁- and T₂-weighted Magnetic Resonance Dual Contrast by Single Core Truncated Cubic Iron Oxide Nanoparticles with Abrupt Cellular Internalization and Immune Evasion.