CD80 and CTLA-4 as diagnostic and prognostic markers in adult-onset minimal change disease: a retrospective study.

ABSTRACT:

Background

Minimal change disease (MCD) is a form of idiopathic nephrotic syndrome. Compared to children, adult-onset MCD patients are reported to have delayed responses to glucocorticoid treatment. Several studies of children have suggested detecting urinary CD80 levels to diagnose MCD. There are no effective diagnostic methods to distinguish steroid-sensitive MCD from steroid-resistant MCD unless treatments are used.

Methods

In a total of 55 patients with biopsy-proven MCD and 26 patients with biopsy-proven idiopathic membranous nephropathy, CD80 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) levels in serum, urine and renal tissue were analyzed.

Results

Steroid-sensitive MCD patients in remission had lower urinary CD80 levels and higher CTLA-4 levels than patients i

SUBMITTER: Zhao B 

PROVIDER: S-EPMC6078067 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature