Correlation of tryptophan metabolites with connectivity of extended central reward network in healthy subjects.

ABSTRACT:

Objective

A growing body of preclinical and clinical literature suggests that brain-gut-microbiota interactions play an important role in human health and disease, including hedonic food intake and obesity. We performed a tripartite network analysis based on graph theory to test the hypothesis that microbiota-derived fecal metabolites are associated with connectivity of key regions of the brain's extended reward network and clinical measures related to obesity.

Methods

DTI and resting state fMRI imaging was obtained from 63 healthy subjects with and without elevated body mass index (BMI) (29 males and 34 females). Subjects submitted fecal samples, completed questionnaires to assess anxiety and food addiction, and BMI was recorded.

Results

The study results demonstrate

SUBMITTER: Osadchiy V 

PROVIDER: S-EPMC6078307 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature