Neutral lineage tracing of proliferative embryonic and adult mammary stem/progenitor cells.

ABSTRACT: Mammary gland development occurs over multiple phases, beginning in the mammalian embryo and continuing throughout reproductive life. The remarkable morphogenetic capacity of the mammary gland at each stage of development is attributed to the activities of distinct populations of mammary stem cells (MaSCs) and progenitor cells. However, the relationship between embryonic and adult MaSCs, and their fate during different waves of mammary gland morphogenesis, remains unclear. By employing a neutral, low-density genetic labelling strategy, we characterised the contribution of proliferative stem/progenitor cells to embryonic, pubertal and reproductive mammary gland development. Our findings further support a model of lineage restriction of MaSCs in the postnatal mammary gland, and highlight ext

SUBMITTER: Lloyd-Lewis B 

PROVIDER: S-EPMC6078330 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature