Dissecting recipient from donor contribution in experimental kidney transplantation: focus on endothelial proliferation and inflammation.

ABSTRACT: Kidney transplantation (Tx) is considered the only definite treatment for end-stage kidney disease (ESKD) patients. The increasing prevalence of ESKD has necessitated the introduction of transplantation with kidneys from suboptimal donors. There is, however, still a lack of fundamental and longitudinal research on suboptimal kidney transplants. Specifically, there is a demand for accurate pre-Tx predictors of donor kidney function and injury to predict post-Tx outcome. In the present study, we combine rat models of chronic kidney disease (CKD) and renal Tx to dissect the effects of healthy and CKD renal grafts on healthy and CKD recipients. We show that renal function at 6 weeks post-Tx is exclusively determined by donor graft quality. Using cell tracking within enhanced green fluorescent

SUBMITTER: Papazova DA 

PROVIDER: S-EPMC6078404 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature