No association between MGP rs1800802 polymorphism and stenosis of the coronary artery.

ABSTRACT:

Background and objectives

Matrix Gla protein (MGP) was originally isolated from bone but it is known to be expressed in several tissues including kidney, lung, heart, cartilage and vascular smooth muscle cells (VSMC) of the blood vessel wall. Since it inhibits calcification in subendothelial space of vessels thus, we evaluated the association of rs1800802(T > C) polymorphism and stenosis of the coronary artery.

Design and setting

Cross-sectional case-control.

Subjects and methods

One hundred eighty two subjects recruited on the basis of study protocol from who underwent coronary angiography. The controls (n=70) had normal coronary arteries (up to 5% stenosis). The patients (n=112) subdivided into three subgroups; single-vessel disease (SVD), two-vessel disease (2VD) a

SUBMITTER: Roustazadeh A 

PROVIDER: S-EPMC6078625 | biostudies-literature | 2013 Mar-Apr

REPOSITORIES: biostudies-literature