Finding lost genes in GWAS via integrative-omics analysis reveals novel sub-networks associated with preterm birth.

ABSTRACT: Maternal genome influences associate with up to 40% of spontaneous preterm births (PTB). Multiple genome wide association studies (GWAS) have been completed to identify genetic variants associated with PTB. Disappointingly, no highly significant SNPs have replicated in independent cohorts so far. We developed an approach combining protein-protein interaction (PPI) network data with tissue specific gene expression data to "find" SNPs of modest significance to identify candidate genes of functional importance that would otherwise be overlooked. This approach is based on the assumption that "high-ranking" SNPs falling short of genome wide significance may nevertheless indicate genes that have substantial biological value in understanding PTB. We mapped highly-ranked candidate SNPs from a meta

SUBMITTER: Brubaker D 

PROVIDER: S-EPMC6078636 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature