Causal association of body mass index with hypertension using a Mendelian randomization design.

ABSTRACT: Observational studies have shown that obesity is a major risk factor for hypertension, but unmeasured confounding factors may exist. We used Mendelian randomization (MR) to assess the causal effect of obesity on hypertension.The MR analysis was performed in a well-defined community cohort study of 8832 middle-aged (40-69 years) adults in Korea enrolled from 2001 to 2013. We used baseline hypertension and newly diagnosed hypertension during the 10-year follow-up period as the outcome variable. Genetic risk score associated with body mass index (BMI GRS) was used as the instrumental variable (IV) to measure the causal relationship between obesity and hypertension. The IV estimate of causal odds ratio (OR) was derived using the Wald ratio estimator and then exponentiation to express the resul

SUBMITTER: Lee MR 

PROVIDER: S-EPMC6078651 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature