Association between IL-1β + 3954C/T polymorphism and myocardial infarction risk: A meta-analysis.

ABSTRACT:

Background

Many studies have reported that the IL-1β + 3954C/T polymorphism (rs1143634) is related to myocardial infarction (MI). To classify the association between IL-1β + 3954C/T and MI susceptibility, we performed a meta-analysis.

Methods

We retrieved relevant literature from electronic databases (Embase, PubMed, Cochrane, and Web of Science). Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated with a fixed effect model or a random effect model. Sensitivity analysis and publication bias results are also presented.

Results

Nine eligible studies (2299 controls and 2203 cases) were included. The pooled results showed a significant relationship between MI and IL-1β + 3954C/T in an allelic comparison (T vs C: OR = 1.13, 95% CI 1.02-1.25, I =

SUBMITTER: Fang Y 

PROVIDER: S-EPMC6078675 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature