The impact of night-shift work on platelet function in healthy medical staff.

ABSTRACT: OBJECTIVES:Rotating shift work has been reported to increase the risk of cardiovascular diseases. Vascular endothelial dysfunction and platelet activation are among the leading causes of thrombus formation in patients with myocardial infarction or stroke. Endothelial function has been shown to be impaired immediately after night-shift work; however, it is not known whether platelets are also activated. The aim of this study was to investigate the acute impact of night-shift work on platelet function. METHODS:This observational study included 11 healthy medical staff members (seven women, median age 32 years). We examined each subject's platelet aggregation rates and the serum concentrations of eicosanoid mediators after night-shift work and on day-shift work without preceding night-shift w

SUBMITTER: Nakao T 

PROVIDER: S-EPMC6078842 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature