CTCF Regulates Otic Neurogenesis via Histone Modification in the Neurog1 Locus.

ABSTRACT: The inner ear is a complex sensory organ responsible for hearing and balance. Formation of the inner ear is dependent on tight regulation of spatial and temporal expression of genes that direct a series of developmental processes. Recently, epigenetic regulation has emerged as a crucial regulator of the development of various organs. However, what roles higher-order chromatin organization and its regulator molecules play in inner ear development are unclear. CCCTC-binding factor (CTCF) is a highly conserved 11-zinc finger protein that regulates the three-dimensional architecture of chromatin, and is involved in various gene regulation processes. To delineate the role of CTCF in inner ear development, the present study investigated inner ear-specific Ctcf knockout mouse embryos (P

SUBMITTER: Shin JO 

PROVIDER: S-EPMC6078853 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature