Ontology highlight
ABSTRACT:
SUBMITTER: Luijk R
PROVIDER: S-EPMC6079029 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Nature communications 20180806 1
Identification of causal drivers behind regulatory gene networks is crucial in understanding gene function. Here, we develop a method for the large-scale inference of gene-gene interactions in observational population genomics data that are both directed (using local genetic instruments as causal anchors, akin to Mendelian Randomization) and specific (by controlling for linkage disequilibrium and pleiotropy). Analysis of genotype and whole-blood RNA-sequencing data from 3072 individuals identifi ...[more]