Cbl-b deficiency provides protection against UVB-induced skin damage by modulating inflammatory gene signature.

ABSTRACT: Exposure of skin to ultraviolet (UV) radiation induces DNA damage, inflammation, and immune suppression that ultimately lead to skin cancer. However, some of the pathways that regulate these events are poorly understood. We exposed mice to UVB to study its early effects in the absence of Cbl-b, a known suppressor of antitumor immune response in the skin. Cbl-b^-/- mice were protected from UV-induced cell damage as shown by the lower number of cyclobutane pyrimidine dimers and sunburn cells in exposed skin compared to wild-type mice. Microarray data revealed that deficiency of Cbl-b resulted in differential expression of genes involved in apoptosis evasion, tumor suppression and cell survival in UV-exposed skin. After UVB, Cbl-b^-/- mice upregulated gene expression patte

SUBMITTER: Singh TP 

PROVIDER: S-EPMC6079082 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature