A novel environment-evoked transcriptional signature predicts reactivity in single dentate granule neurons.

ABSTRACT: Activity-induced remodeling of neuronal circuits is critical for memory formation. This process relies in part on transcription, but neither the rate of activity nor baseline transcription is equal across neuronal cell types. In this study, we isolated mouse hippocampal populations with different activity levels and used single nucleus RNA-seq to compare their transcriptional responses to activation. One hour after novel environment exposure, sparsely active dentate granule (DG) neurons had a much stronger transcriptional response compared to more highly active CA1 pyramidal cells and vasoactive intestinal polypeptide (VIP) interneurons. Activity continued to impact transcription in DG neurons up to 5 h, with increased heterogeneity. By re-exposing the mice to the same environment, we iden

SUBMITTER: Jaeger BN 

PROVIDER: S-EPMC6079101 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature