Network Architecture and Mutational Sensitivity of the C. elegans Metabolome.

ABSTRACT: A fundamental issue in evolutionary systems biology is understanding the relationship between the topological architecture of a biological network, such as a metabolic network, and the evolution of the network. The rate at which an element in a metabolic network accumulates genetic variation via new mutations depends on both the size of the mutational target it presents and its robustness to mutational perturbation. Quantifying the relationship between topological properties of network elements and the mutability of those elements will facilitate understanding the variation in and evolution of networks at the level of populations and higher taxa. We report an investigation into the relationship between two topological properties of 29 metabolites in the C. elegans metabolic network

SUBMITTER: Johnson LM 

PROVIDER: S-EPMC6079199 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature