Characterization of Bacteriophages Infecting Clinical Isolates of Clostridium difficile.

ABSTRACT: Clostridium difficile is recognized as a problematic pathogen, causing severe enteric diseases including antibiotic-associated diarrhea and pseudomembranous colitis. The emergence of antibiotic resistant C. difficile has driven a search for alternative anti-infection modalities. A promising strategy for controlling bacterial infection includes the use of bacteriophages and their gene products. Currently, knowledge of phages active against C. difficile is still relatively limited by the fact that the isolation of phages for this organism is a technically demanding method since bacterial host themselves are difficult to culture. To isolate and characterize phages specific to C. difficile, a genotoxic agent, mitomycin C, was used to induce temperate phages from 12

SUBMITTER: Phothichaisri W 

PROVIDER: S-EPMC6079236 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature