Detrimental Outcomes of Unmasking Cryptococcal Meningitis With Recent ART Initiation.

ABSTRACT:

Background

Increased antiretroviral therapy (ART) availability has been associated with more patients developing cryptococcosis after ART initiation. Despite this changing epidemiology, data regarding cryptococcal meningitis in those already receiving ART are limited. We compared clinical presentations and outcomes among ART-naïve and ART-experienced Ugandans.

Methods

We prospectively enrolled 605 HIV-infected persons with first-episode cryptococcal meningitis from August 2013 to May 2017 who received amphotericin-based combination therapy. We classified participants by ART status and ART duration and compared groups for 2-week survival.

Results

Overall, 46% (281/605) of participants were receiving ART at presentation. Compared with those not receiving ART, those rece

SUBMITTER: Rhein J 

PROVIDER: S-EPMC6080052 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature